Conference submissions

High volume, low cost production of nanobiosensors using flexographic printing technique

Kar Seng Teng1 , Abdulaziz Assaifan2 , Jonathan Lloyd3 , Siamak Samavat4 , Davide Deganello5

1Swansea University, College of Engineering, United Kingdom
2Swansea University, College of Engineering, United Kingdom
3Swansea University, College of Engineering, United Kingdom
4Swansea University, College of Engineering, United Kingdom
5Swansea University, College of Engineering, United Kingdom

Abstract

The use of nanoscale electronic materials as sensing elements in biosensors offer many advantages, such as ultra-high sensitivity, excellent specificity, rapid response time and minimal sample volume for detection. The sensitivity of such nanobiosensor allows early detection of diseases, which could enhance the chances for successful treatments. There has been much research interest and effort in developing nanobiosensors as point-of-care diagnostic devices that has an expected market value of US$37 billion by 2021 globally. However, one of the major challenges in bringing the technology to mass-market is the cost of manufacturing these nanobiosensors. For example, most nanobiosensors are fabricated using expensive cleanroom facilities and complex processes, which lead to high production cost and hence making them commercially unviable. Therefore, the ability to scale-up production of nanobiosensors at very low cost is commercially attractive. In this talk, the novel use of flexographic printing technique for the fabrication of nanobiosensors will be presented. Such roll-to-roll printing technique is ideal for volume production of nanobiosensors at very low cost. The technique enables high-speed direct-patterning of nanomaterials on to a surface [1]. Furthermore, it allows the use of organic substrates, which would significantly reduce the cost of these devices. Metal-oxide nanowire chemiresistive gas sensor and metal nanoparticle electrochemical biosensor were fabricated using the printing technique [2-4]. An intricate nanotextured surface at flexographic printed ZnO thin film, which exhibited high specific surface area, was developed for biosensing applications. Such nanobiosensors is ideal for large scale screening of diseases at very low cost with excellent sensitivity [5]. References 1. J.S. Lloyd, C.M. Fung, D. Deganello, R.J. Wang, T.G.G. Maffeis, S.P. Lau and K.S. Teng, ‘Flexographic printing-assisted fabrication of ZnO nanowire devices’, Nanotechnology 24, 195602 (2013) 2. J. Benson, C.M. Fung, J.S. Lloyd, D. Deganello, N.A. Smith and K.S. Teng, ‘Direct patterning of gold nanoparticles using flexographic printing for biosensing applications’, Nanoscale Research Letters 10, 127 (2015). 3. J.S. Lloyd, C.M. Fung, E.J. Alvim, D. Deganello and K.S. Teng, ‘UV photodecomposition of zinc acetate for the growth of ZnO nanowires’, Nanotechnology 26, 265303 (2015). 4. C.M. Fung, J.S. Lloyd, S. Samavat, D. Deganello and K.S. Teng, ‘Facile fabrication of electrochemical ZnO nanowire glucose biosensor using roll to roll printing technique’, Sensors and Actuators B: Chemical 247, 807 (2017). 5. A.K. Assaifan, J.S. Lloyd, S. Siamak, D. Deganello, R.J. Stanton and K.S. Teng, ‘Nanotextured surface on flexographic printed ZnO thin films for low-cost non-faradaic biosensors’, ACS Applied Materials and Interfaces 8, 33802 (2016).